hi,
From isapi log errors would appear tomcat at the CF end is not responding to the iis tomcat connector. Likely you need to make some adjustments or tune values to server.xml in cfusion\runtime\conf.
What values? This CF11 blog entry may help since the details also apply to CF10.
http://blogs.coldfusion.com/post.cfm/coldfusion-11-iis-connector-tuning
Keep in mind when making adjustments to server.xml matching changes need to be applied to workers.properties in config\wsconfig\N.
You could also do some monitoring with free jdk tools like jconsole to help know what tuning values would suit the type of load best. Java and tomcat monitoring tho is time and effort so reply on thread if you want to know more about how to do monitoring.
HTH, Carl.
